Fig. 2

SHED-Exo promote LPS-induced chronic wound healing. a Representative wound images from mice treated with LPS, LPS containing exosomes (LPS + Exo), LPS containing exosomes and 3-MA(LPS + Exo + 3MA), and LPS containing rapamycin (LPS + RAPA) over 14 days of healing period. b Comparison of the percentages of the open wound size over 10 days healing period between LPS, LPS + Exo, LPS + Exo + 3MA and LPS + RAPA groups. n = 5. c H&E staining images of full-thickness wounds on days 10, arrows indicate newly formed dermal appendages, scale bar: 1000 μm. d Masson staining images of full-thickness wounds on days 10, arrows indicate newly formed dermal appendages. Scale bars (low power field), 3 mm. Scale bars (high power field), 200 µm. e Representative immunohistochemistry of CD31 within incisional wounds. Scale bars (low power field), 100 µm. Scale bars (high power field), 30 µm