Fig. 8
From: Advances of nano drug delivery system for the theranostics of ischemic stroke
Schematic design and characterization of T7&SHp-P-LPs. A Designs for ZL006 loaded T7 and PEGylated dual targeted nanocarrier under the SHp conjugation in terms of focal cerebral ischemia treatment through transcytosis under the mediation of transferrin receptor and endocytosis under the mediation of glutamate receptor. B ZL006 release profiles from T7&SHp-P-LPs in PBS (pH 5.5) and PBS (pH 7.4) containing 0.1% Tween-80 (n = 3). C Ex vivo fluorescent image of DiR-labeled P-LPs, T7-P-LPs, SHp-P-LPs and T7&SHp-P-LPs in the ischemic brain at 6 and 24 h. Arrow: ischemic cerebral hemisphere. Reproduced with permission from [140]. Copyright 2016, Elsevier