Fig. 7
From: Nanoparticles mediated tumor microenvironment modulation: current advances and applications
Copyright 2016 by Chen [62]. b Schematic represents the development of HPMRCD and its potential application mechanism in MRI imaging, chemophotodynamic therapy. Copyright 2021 by Wang [63]. c (i) Schematic representation of the synthesis of carbon dot doped C3N4 and PCCN and corresponding PDT enhanced by 630Â nm light driven water splitting and corresponding water splitting mechanism, (ii)quantification of PCCN induced oxygen production, hypoxia reversion and ROS generation. Copyright 2016 by Zheng [65]. d Schematic shows the PLANT system induced tumor normalization. Copyright 2018 by Zheng [66]. e (i) Illustration of the development of MnPcS@HPO NPs and corresponding SDT antitumor activity, (ii) mechanism involved in the conversion of O2 to 1O2, and (iii-v) tumor volume, weight and corresponding photograph images after SDT. Copyright 2022 by Yin [68]
Reprogramming the TMEs by alleviating hypoxia: a (i) Schematic represents the development of albumin-decorated MnO2 nanoparticles with Ce6 and Pt conjugation (HMCP) and simultaneous production of oxygen generation H2O2 solution, (ii) cell viability after treating with HMCP nanoparticles, and (iii) cell viability after PDT (irradiation with 660Â nm) with and without addition of H2O2.