Fig. 4

Evaluation of selectivity, stability, and reproducibility of the developed SERS platform. A Representative SERS spectra and B mean SERS intensity obtained from the detection of miRNA-499, miRNA-328, miRNA-208, miRNA-21 and their mixture. C SERS spectra and D Raman intensities obtained from 7 days of the same sample. E SERS spectra and F Raman intensities obtained from 10 different biological samples over 10 days. All of the measurements were performed at a miRNA concentration of 1 pM. Data depicted in B, D, and F are the intensities of the peaks at 1340 cm⁻¹