Fig. 8

In vivo therapeutic efficacy of PGN in B16F10 tumor-bearing C57 mice. A Time-dependent tumor growth curves of mice after treatment with saline, free CQ, DTX, CQ + DTX, d-PN, d-PRN and d-PGN. B, C Tumors were harvested, and the tumor weight was monitored. D The body weight of mice during the treatments. E H&E, TUNEL staining of obtained tumor tissues, H&E scale bars: 100 μm, TUNEL scale bars: 50 μm. F Analysis of LC3 intensity based on immunofluorescence staining; scale bars: 100 μm. Data are expressed as the mean ± s.d. (n = 7).