Fig. 6

Regulation of miR-21-5p on PTEN and PVT1. HUVECs were randomly distributed into three groups that received different treatments. A, B Predicted binding sites between miR-21-5p and PTEN and PVT1 respectively by the database (starbase.sysu.edu.cn/; mirtarbase.mbc.nctu.edu.tw/) and relative Luciferase unit of three groups treated with the wild type (WT) or Mutated (Mut) versions of A PTEN and B PVT1. C qPCR results of relative miR-21-5p and PVT1 levels. D Western Blotting results of key proteins such as PI3Kγ, PIK3R1, P-Akt, IL-17 and E its statistical data. *p < 0.05, **p < 0.01, ***p < 0.001