Scheme 1

Schematic illustration of the triple action NP@Pt-1 for chemotherapy, PDT and cancer immunotherapy. A Chemical structures of Pt-1 and the ROS sensitive polymer carrier (P1) and their assembly into NP@Pt-1. B Illustration of the triple action of NP@Pt-1. NP@Pt-1 were injected to CT-26 tumor bearing mice and were then accumulated to the tumor site. Under light irradiation (420 nm), numerous ROS was generated to break down the polymer chain (thioketal bonds), resulting in the release of Pt-1. Pt-1 then chelated with intracellular DNA to induce apoptosis for chemotherapy. Moreover, the ROS can on the one hand damage the cell membranes, proteins and DNAs in cancer cells for PDT. On the other hand, it can induce ICD effect by sending out “eat me” signal for cancer immunotherapy