Fig. 11
From: Recent advances in smart nanoplatforms for tumor non-interventional embolization therapy
The mimic nanoparticles for precise embolization. a Platelet-mimicking nanoparticles for artificial coagulation. b The transformation of pNPs into apNFs. c The active targeting of pNPs to the tumor vessels. d The formation of artificial clots indicated by H&E staining and CLSM images. e Tumor growth was inhibited by pNP-induced tumor thrombosis [89]. f Comparison of fibrillogenesis in natural laminin and peptide-based nanoparticles mimicking laminin. g The transformation of LMMP morphology at pH 6.5. h The targeting effect of LMMP NPs when incubated with the microthrombus and collagen. i The entanglement of LMMP NFs and RBCs. j Vessel occlusion colocalized with LMMP NFs. k Tumor growth inhibition after intravenous injection with LMMP NPs [92]. Copyright©2020 American Chemical Society