Fig. 4
From: Recent advances in smart nanoplatforms for tumor non-interventional embolization therapy
Thrombosis in the tumor triggers enhanced hypoxia-activated prodrug therapy. a Schematic fabrication of Th-TPZ@MOF-FA and the mechanism of degradation and prodrug activation. b Schematic illustration of the formation of thrombosis in the tumor and enhanced hypoxia-activated prodrug therapy. c Blood clot formation in vitro and thrombosis in tumors treated with  intravenous injection of Th-TPZ@MOF-FA. d CD 41-stained tumor sections at different time points after the administration of Th-TPZ@MOF-FA. e The in vivo antitumor activity of Th-TPZ@MOF-FA [32]. Copyright©2021 Wiley-VCH GmbH