Scheme 1

The fabrication of aligned electrospun PLLA nanofibers and their use in wound healing. A Schematic diagram showing the preparation of aligned electrospun nanofibers. B Aligned nanofibers promote M2 macrophage polarization. C The conditioned medium of macrophages cultured on aligned nanofibers promoted collagen secretion by fibroblasts. D Aligned nanofibers inhibit macrophage M1 polarization via the JAK-STAT and NF-κB signaling pathways. E Aligned nanofibers facilitate skin wound healing in mice