Fig. 5

Local gel scaffold for abscopal anticancer immune response. A Mice were inoculated with tumor cells in the right and left flanks. Control mice were untreated, whereas treated mice were implanted with DOX-JQ1@Gel only on the left flank. B In vivo bioluminescence imaging of 4T1-Luc breast cancer in response to local DOX-JQ1@Gel treatment. C Left and right tumor growth curves on day 10 in untreated and treated mice. D Representative flow cytometry analysis of CD4⁺ and CD8⁺ T cells in tumors of control and treated mice. E, F Corresponding quantification results of CD4⁺ and CD8⁺ T cells in tumors of control and treated mice. G PD-L1 expression of tumor cells of the control and treated mice