Fig. 12
From: Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging
a Step-growth polymerization is used to synthesize P1 from pro-E2 and PEG dithiol monomers to create a copolymer that can be processed into thin films and electrospun fibers that deliver E2 as they degrade via hydrolysis. b Three different neuron culture models are used to demonstrate that electrospun P1 fibers provide contact guidance for extending neurites, and P1 films are neurotrophic and neuroprotective against oxidative stress (the figure is reproduced from D'Amato et al. [298] with required copyright permission)