Fig. 6
From: Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma
The features of tumor angiogenesis. Tumor angiogenesis is a complex process of interaction between tumor cells and endothelial cells. The main process is as follows: endothelial cells are stimulated by proangiogenic growth factors secreted by tumor cells. After degrading, endothelial cells proliferate under the action of various chemokines, form lumen with pericytes under the action of adhesion molecules, and generate new tumor blood vessels after maturation and stabilization. Tumor angiogenesis is an important basis for tumor growth, invasion, and metastasis. This process is regulated by various angiogenic growth-promoting or inhibitory factors and signaling pathways