Table 5 Overview of TEXs cargos and their biological effects in angiogenesis
From: Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma
Donor cell | Exosomal cargos | Receiving cell | Biological effects | References |
|---|---|---|---|---|
GBM cells | VEGF-C | Endothelial cells | Target Hippo/TAZ signal Stimulate cell viability, migration, and tubulization | [125] |
GBM cells | linc-CCAT2 | HUVECs | Target VEGFA/TGF/Bcl-2/Bax/caspase-3 signal | [126] |
Promote cell migration, proliferation, tubular formation structure formation in vitro and arteriole in vivo | ||||
Glioma stem cells | miR-21 | Endothelial cells | Target miR-21/VEGF signal | [127] |
GBM cells | VEGF-A | Endothelial cells | Promote angiogenesis and vascular permeability | [128] |
Glioma stem cells | miR-26a | HUVECs | Target PTEN/PI3K/Akt Stimulate cell viability, migration, and tubulization | [129] |
GBM cells | miR-182-5p | HUVECs | Target KLF2/KLF4 Stimulate cell proliferation and tubulization | [130] |
GBM cells | miR-148a-3p | HUVECs | Target ERRFI1/EGFR/MAPK Stimulate cell proliferation and tubulization | [131] |
Glioma stem cells | miR-944 | HUVECs | Target VEGFC/AKT/ERK Inhibit cell viability, migration, and tubulization | [132] |
GBM cells | circGLIS3 | Endothelial cells | Target Ezrin T567 Stimulate tubulization | [133] |