Fig. 8
From: Protection of zero-valent iron nanoparticles against sepsis and septic heart failure
RNA sequencing-identified transcriptome regulated by nanoFe in septic mice. A A volcano plot displayed differentially expressed mRNAs. The blue and red parts indicated > twofold decreased or increased expression of the dysregulated mRNAs in cardiac tissues, respectively (P < 0.05). B Cluster analysis of differential genes in each group. C Top 20 GO enrichment for the up-regulated gene categories between the CLP group and the nanoFe + CLP group (P < 0.05). D Top 20 GO enrichment for the downregulated gene categories between the CLP group and the nanoFe + CLP group. E Top 20 KEGG enrichment for up-regulated pathways between the CLP group and the nanoFe + CLP group (P < 0.05). F Top 20 KEGG enrichment for downregulated pathways between the CLP group and the nanoFe + CLP group (P < 0.05)