Fig. 4

Tumor targeting of Stealth Exo@RB under the irradiation of 532 nm laser. A Schematic illustration of these experiments. B Representative images show exosomes uptake by Raw264.7 cells. Different groups of exosomes were labelled with DiO and then irradiated by 0.1 w cm⁻² 532 nm laser for 5 min. After 4 h/12 h/24 h, Images were taken under fluorescence microscope. Scale bar = 20 μm. C Representative in vitro fluorescent images of the DiR-labeled exosomes in tumors and main organs. n = 6 mice. D qPCR analysis of relative expression of Cel-miR-54 in various organs and tumors in mice treated with Stealth Exo and Stealth Exo + Laser. U6 served as an internal control. Data are expressed as mean ± SEM of six independent biological samples. *p < 0.05 by t-test