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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Metformin and histone deacetylase inhibitor based anti-inflammatory nanoplatform for epithelial-mesenchymal transition suppression and metastatic tumor treatment

Fig. 4

Inhibitory effects on cancer stem cell-like 4T1 cells. A Representative morphology of tumor spheres formed by cancer stem cell-like 4T1 cells incubated with free metformin, free OA-Met, free pro-DHA, free triptolide, HAOPs, HAOTs, DexOPTs and HAOPTs. Scale bar, 100 µm. B Quantitative analysis of the MSFE on cancer stem cell-like 4T1 cells. Data were represented as mean ± SD (n = 3), *P < 0.05, **P < 0.01, ****P < 0.0001. C Flow cytometry analysis of CD44+/CD24−/low subpopulation in cancer stem cell-like 4T1 cells

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