Table 1 Pharmacokinetic parameters of 8 mg/kg FLQY2 in different formulations after intragastric administration
Parameters (unit) | FLQY2-SD, 1:15 | FLQY2-SD, 1:10 | FLQY2-PM, 1:15 | Cyclodextrin suspension |
|---|---|---|---|---|
Cmax (ng/mL) | 835.0 ± 53.6a | 206.3 ± 40.9a | 133.2 ± 18.6a | 37.9 ± 4.9 |
Tmax (h) | 1.3 ± 0.5 | 1.7 ± 0.5 | 1.7 ± 0.5 | 1(12) |
MRT (h) | 15.1 ± 1.4 | 19.69 ± 3.2 | 21.4 ± 2.7 | 25.4 ± 3.4 |
T1/2 (h) | 10.0 ± 1.2 | 10.2 ± 1.6 | 12.4 ± 2.1 | 10.3 ± 1.4 |
AUC0-72 h (h·ng/mL) | 10820.2 ± 936.3a | 3507.8 ± 388.8a | 3242.3 ± 353.2a | 875.6 ± 58.6 |