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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: αvβ3 integrin-specific exosomes engineered with cyclopeptide for targeted delivery of triptolide against malignant melanoma

Fig. 3

Cellular uptake and internalization mechanisms of cRGD-Exo/TP. A CLSM images of A375 cells incubated with Exo/TP, cRGD-Exo/TP, and HaCaT cells incubated with cRGD-Exo/TP for 4 h. Scale bar = 50 μm. B The MFI of A375 and HaCaT cells treated with PKH67-labeled Exo/TP or cRGD-Exo/TP. C Intracellular TP content was measured by UHPLC-MS/MS after the A375 cells were treated with free TP, Exo/TP, or cRGD-Exo/TP at different times. D Flow cytometry images of A375 cells treated with low temperature or different inhibitors. E The MFI of A375 cells pretreated with low temperature or different inhibitors. *p < 0.05, **p < 0.01, ***p < 0.001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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