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Table 1 Pharmacokinetic parameters of TP solution, Exo/TP, and cRGD-Exo/TP

From: αvβ3 integrin-specific exosomes engineered with cyclopeptide for targeted delivery of triptolide against malignant melanoma

Parameters

Unit

cRGD-Exo/TP

Exo/TP

TP (solution)

AUC∞

ng/mL*h

21,137.30 ± 4578.44

1767.83 ± 552.66

1400.43 ± 81.44

Cmax

ng/mL

1731.79 ± 413.55

1241.93 ± 232.39

612.44 ± 100.02

t1/2

h

27.14 ± 2.55

2.337 ± 0.34

0.31 ± 0.06

MRT

h

36.57 ± 3.35

2.80 ± 0.29

0.06 ± 0.03

CL

mL/h/kg

151.45 ± 30.86

1904.31 ± 564.64

2193.14 ± 124.42

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Journal of Nanobiotechnology

ISSN: 1477-3155

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