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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Directing ricin-based immunotoxins with targeting affibodies and KDEL signal peptide to cancer cells effectively induces apoptosis and tumor suppression

Fig. 1

In vitro measurements of dose-dependent cytotoxicity. Dose-dependent cytotoxicity of RTA-KDEL, HER2Afb-RTA, HER2Afb-RTA-KDEL and doxorubicin in HER2-overexpressing A NIH3T6.7 and B SK-BR-3 cells; RTA-KDEL, EGFRAfb-RTA, EGFRAfb-RTA-KDEL and doxorubicin in EGFR-overexpressing C MDA-MB-468 and D A431 cells; HER2Afb-RTA, HER2Afb-RTA-KDEL, EGFRAfb-RTA, and EGFRAfb-RTA-KDEL in E MCF-10A, using CCK-8 assay. F Half-maximal effective concentration (EC50) values of HER2Afb-RTA, HER2Afb-RTA-KDEL, EGFRAfb-RTA, EGFRAfb-RTA-KDEL, and doxorubicin against each cell. Curves were fitted using a Hill equation to determine EC50 values. All data shown are means ± standard deviation (SD); n = 3

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Journal of Nanobiotechnology

ISSN: 1477-3155

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