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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Hypertoxic self-assembled peptide with dual functions of glutathione depletion and biosynthesis inhibition for selective tumor ferroptosis and pyroptosis

Fig. 2

GSH-dependent cytotoxicity and depletion of intracellular GSH. A, B Cytotoxicity and IC50 values of NSBSO against different cells after incubation for 12 h and 24 h. C–E Cytotoxicity of NSBSO and other formulations against 3T3 cells, 4T1 cells and B16 cells after incubation for 12 h. F The cell viability of NSBSO in 4T1 and B16 cells w or w/o pre-treatment of GCL inhibitor (Data are presented as mean ± SD, n = 4; ***P < 0.001 and ****P < 0.0001). G, H GSH/GSSG level in 4T1 cells and B16 cells treated with 10 μM formulations for different duration (Data are presented as mean ± SD, n = 3)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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