Fig. 5
(Reprinted with permission from Ref [61] Copyright © 2020, Journal of Cellular and Molecular Medicine, Jin Qi et al.)
Schematic diagram of the role of exosomal miR-21-5p derived from MSCs in regulating the progression of OS cells. MSCs transported miR-21-5p to sarcoma cells via exosomes. Exosomal miR-21-5p targeted PIK3R1 gene and activated PI3K/Akt/mTOR pathway, thus resulting in sarcoma proliferation, invasion, and survival