Fig. 3

pH sensitivity, Fe²⁺ complexation, and movability of AINR in vitro. A TEM images of F68@TA/CDDP at different pHs for 1 h. B Release profile of CDDP at different pHs (n = 3). C TEM images of F68@TA@Ag after treated by different concentration of H₂O₂ for 3 h. D Release profile of Ag⁺ after treatment with different concentration of H₂O₂ for 3 h (n = 3). E Fe²⁺ content chelation by F68@TA at different molar ratio of F68@TA and Fe²⁺ after 12 h chelation (n = 3). The molar weight of F68@TA was set as 1 μmol which was calculated by TA in F68@TA. F TBE-PAGE gel electrophoretogram of m1A DNA repair efficiency incubated with TA or F68@TA under different concentration of Fe²⁺ and G semi-quantitative analysis of repaired DNA. H Snapshots of a typical trajectory at 25 mM H₂O₂. The statistical analysis was performed by one-way ANOVA analysis. (n = 4, *p < 0.05, ** p < 0.01, *** p < 0.001)