Fig. 4

HHP-EXO improves TAC-induced myocardial hypertrophy and cardiac fibrosis. A Representative gross morphology of the hearts and the HE and WGA stained ventricular sections among groups. B Quantification of relative cell surface area of left ventricular sections stained with WGA in Fig. 4A (left panel). Quantification of the expression of Myh7/Myh6 ratio, Acta1, Nppa and Nppb in left ventricular tissues of different animal groups as described in (A) (right panel) (n = 4–8). C Left ventricular sections stained with Masson’s staining (left panel) (n = 4–8). D Quantitation of fibrotic area in C (right panel) and the expression of fibrotic genes Col1a1, Col3a1, Fn1 and Ctgf in left ventricular tissues among groups (n = 4–8). Gene expression was normalized to that of GAPDH. Data are presented as Mean ± SEM, with *P < 0.05 and **P < 0.01