Fig. 4
From: BMSC exosome-enriched acellular fish scale scaffolds promote bone regeneration
In vivo biosafety evaluation. (a, b) H&E and immunohistochemical of F4/80 staining of the skin from mice implanted with or without DE-FS for 2 weeks. Scale bar was 400 μm. (c) H&E-stained samples obtained from the heart, liver, spleen, lung, and kidney of mice implanted with or without DE-FS for 2 weeks. Scale bar was 400 μm. (d) Blood biochemistry analysis of mice after implantation with or without DE-FS for 2 weeks with examined parameters including white blood cell (WBC) count, red blood cell (RBC) count, lymphocyte (LYM), monocyte (MON), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and platelets (PLT).