Fig. 6
From: In vivo fluorescence imaging: success in preclinical imaging paves the way for clinical applications
Non-invasive transcranial NIR-II fluorescence imaging of brain tumor using CH1055-PEG. A Photograph of a nude mouse before NIR-II imaging. B Graphic representation showing the location of brain tumor. T2-colour weighted MRI images of mouse in the sagittal (C) and coronal (D) planes, showing brain tumors at a depth of ~ 4 mm, immediately before NIR-II fluorescence imaging E Transcranial NIR-II fluorescence imaging of brain tumor 6 h post intravenous injection. F Whole-body NIR-II fluorescence imaging 24 h post-injection. Brain vasculature imaging through the scalp and skull of C57BL/6 mouse with shaved head using either (G) ICG (850–900 nm) or H CH1055-PEG (1,300 nm). Adapted with permission from [89]. Copyright (2015) Nature Publishing Group