Fig. 7
From: In vivo fluorescence imaging: success in preclinical imaging paves the way for clinical applications
Deep tissue fluorescence imaging in the NIR-II window using QDs. A In vivo fluorescence imaging of tumor in the NIR-II window with a S/B > 30. (a) Wide-field fluorescence imaging of a tumor xenograft on a mouse after tail vein injection of PEG-coated core/shell PbS/CdS QDs, showing strong signals for 48 h post-injection (b–e). (f) Time course curve of S/B over 96 h post injection. Adapted with permission from [116]. Copyright (2018) National Academy of Sciences. B NIR-II fluorescence imaging of mice using PEG-coated Ag2S superdots. (a) NIR-II fluorescence images of four groups of mice subcutaneously injected with colloidal aqueous dispersions containing Ag2S superdots, commercial Ag2S dots, SWNTs, and LaF3:Nd NPs, using different laser power densities. (b) NIR-II fluorescence images of the left hind limbs of two mice immediately before (top) and 15 s after (bottom) of an intravenous injection of commercial Ag2S dots (left) or superdots (right). (c) Net intensity images obtained from subtracting the background images (top row in b) from the signal images (bottom row in b). (d) Signal-to-background images obtained by dividing the signal intensity images (bottom row in b) by the background images (top row in b). Adapted with permission from [117]. Copyright (2020) Springer Nature