Fig. 1

Radiation sensitization of AGuIX nanoparticles in the breast neoplasm of nude mice. A The process of animal model establishment and sample collection. B Weight changes in the mice 3 weeks after 10 Gy irradiation. C Transplanted tumor volume changes in the mice 3 weeks after 10 Gy irradiation. D Representative images of Ki67 protein expression in the tumor tissues. E Ki67 protein expression in the tumor tissues was analyzed by immunohistochemistry. F Proliferation ability of breast cancer cells MDA-MB-231 after being treated with various conditions. G Proliferation ability of breast cancer cells MDA-MB-468 after being treated with various conditions. H Representative images of the clone formation test using the MDA-MB-231 cell line. I Survival curve of the clone formation test using the MDA-MB-231 cell line, the sensitivity enhancement ratio (SER), calculated according to the survival curve, was 1.66. J Representative images of the clone formation test using the MDA-MB-468 cell line. K Survival curve of the clone formation test using the MDA-MB-468 cell line, the SER, calculated according to the survival curve, was 1.31. All data are represented as means ± standard errors of the means, n ≥ 3 independent replicates and P-values were calculated using two-tailed t-tests. A single asterisk indicates P < 0.05, two asterisks indicate P < 0.01, and three asterisks indicate P < 0.001