Fig. 5

miR-CM1 has cross-kingdom regulatory activity. a Flow diagram to show transcriptome Illumina sequencing in HaCaT cells with miR-CM1 transfection. b The predicted results of miR-CM1 regulating mRNA. c mRNA expression levels of SHLD1, MICAL2, ZNF383, ITPK1, DUSP18, GRAP, ACRBP, PHYHIP, RRN3 and HBEGF in HaCaT cells with miR-CM1 transfection were tested by qRT-PCR. d The matching results between the seed region of miR-CM1 and the 3’UTR region of MICAL2, DUSP18, GRAP and RRN3. e Relative luciferase activity of MICAL2, DUSP18, GRAP and RRN3 with miR-CM1 transfection by dual luciferase reporter gene assay. Data are expressed as mean ± SD (*P < 0.05, **P < 0.01)