Table 3 The application of nanoparticles in other diseases

[114]

EV-mPEGhexPLA

/

Deliver EV

Decrease IL-2, IL-17, and IFN-γ secretion; increase IL-10 secretion; and increase the frequency of CD4 + CD25 + FoxP3 + Treg cells

B10.RIII mice with EAU

[115]

Nano-SOD1

44–45 nm

Deliver SOD1

/

Chinchilla rabbits with immunogenic uveitis induced by injecting normal horse serum

[6]

TA-mPEG-PLGA NPs

40 ~ 100 nm

Deliver TA

Inhibit the expression of IL-17 and IL-10

Lewis rats with EAU induced by interphotoreceptor retinoid binding protein (IRBP) emulsion

[41]

PLGA-GA₂-CUR

250 nm

Deliver CUR

/

Beagles with homologous lens protein-induced uveitis

[33]

TA-SA/PECE

30 nm

Deliver TA-SA

Inhibit the production of NO and TNF-α by activated RAW264.7 macrophages, inhibit IL-6 expression, reduce neutrophil infiltration

Japanese big-eared white rabbits with LPS-induced EIU

[28]

TA-PLC NPs

120 nm

Deliver TA

Decrease the expression of IL-6

Albino rabbits with endotoxin-induced uveitis

[29]

cTA-LNA NPs

198.95 ± 12.82 nm

Deliver TA

Reduce TNF-α levels, reduce inflammatory cells, reduce bleeding and congestion

HET-CAM

[34]

CUR-NPs

161.0 ± 6.0 nm

Load CUR

Downregulate the expression of TNF, IL-1α, IL-6 and MMP-13; inhibit TM cell apoptosis

New Zealand albino rabbits

[50]

PAMAM-PVL-PEG

34 nm

Deliver dehydroepiandrosterone (DHEA) and NMDA

Inhibit microglia/macroglia activation and oxidative stress

C57BL/6 MICE with NMDA-induced RGC degeneration

[55]

FK506 loaded nanomicelle and ciliary neurotrophic factor (CNTF)

100–350 nm

Deliver CNTF and FK506

Inhibit microglial activation

Japanese white rabbits with optic nerve damage caused by reverse arterial clamp clamping