Silver nano-reporter enables simple and ultrasensitive profiling of microRNAs on a nanoflower-like microelectrode array on glass

Table 2 The comparison of different additional amplification strategies for AgNPs-mediated electrochemical miRNA detection

Amplification method	LOD	Linear range	Sample	Refs.
RCA	0.05 fM	0.1 fM–10 nM	Cells/Serum	[24]
HCR	0.39 fM	0.5 fM–1 nM	Cells	[26]
Tetrahedral DNA/SDR	0.4 fM	1 fM–1 nM	Serum	[27]
DSN/AuNPs	0.62 fM	1 fM–1 pM	Plasma	[28]
Walker amplification	32 fM	100 fM–1 μM	Serum	[45]
Graphene/polyaniline	0.2 fM	10 fM–10 μM	Blood	[46]
SDR/polymerase/endonuclease	0.07 fM	1 fM–10 nM	Cells	[47]
AuNPs/biotin/neutravidin	300 fM	500 fM–1 μM	Serum	[48]
SDR/biotin/streptavidin	0.4 fM	1 fM–200 pM	Blood	[49]
Network of MPBA-AgNPs	0.02 fM	0.1 fM–2 pM	Serum	[50]
None	0.56 fM	1 fM–10 pM	Cells	This work

RCA rolling circle amplification, HCR hybridization chain reaction, SDR strand displacement reaction, DSN duplex-specific nuclease, MPBA 4-mercaptophenylboronic acid

ISSN: 1477-3155