Fig. 4

Targeting of XFS materials on the surface of the human lens capsule with MP-peptide conjugates. (A) Illustration of the anterior lens capsule showing general pattern of XFS deposits on its surface. (B) MP-p-IPL showed specific binding to XFS deposits on both central and the peripheral zones of tissue having XFS materials. The non-XFS area of lens capsule (blank spots) showed less or no particles compared to the exfoliated area. (C) MP-p-LPS also showed specific targeting of XFS materials on the surface of the lens capsule. (D) Scrambled MP-p-IPL interacted non-specifically with both XFS deposits and the area of lens capsule surface without XFS deposits. (E) Scrambled MP-p-LPS also showed non-specific interaction with XFS materials. (F) MP without peptide conjugates. As shown in the image, there is a high amount of XFS materials on the central part of the human lens capsule, however, there is not enough binding of MPs to the XFS area. Arrows indicate approximate regions of XFS materials in each tissue sample