Fig. 3

The underlying mechanism of HNP effect on PTT. A The H&E staining of tumor sections of the mice after different treatments (scale bar = 20 μm). B The KEGG enrichment scatterplot of the RNA sequence between HNP and HNP + Laser groups in Hepa 1–6 cells. C The illustration of how PTT enhanced the interaction between tumor cells and NK cells, to activate the cytotoxicity of NK cells to kill tumor cells. D The alteration of cytokines (IL-6, IL-10, and IL-12b) secreted by NK cells in mRNA level (error bars represent the mean ± s.d., one-way ANOVA was used for multiple comparisons; *P < 0.05, **P < 0.01, ***P < 0.001)