Fig. 6

CDs protected chondrocytes against IL-1β-induced extracellular matrix degradation and inflammatory responses. A RT-qPCR analysis results showed CDs effectively protected chondrocytes against IL-1β-induced extracellular matrix degradation. B The reduced level of COLII and induced level of MMP13 was rescued by CDs treatment. C The staining intensity of COLII and MMP13 in IL-1β-stimulated chondrocytes was modulated by CDs. Scar bar: 20 μm. D CDs effectively inhibited IL-1β-induced inflammatory responses. E The concentration of TNF-α and IL-6 in the supernatant from different groups was determined by ELISA kit. *p < 0.05; **p < 0.01; ***p < 0.001