Fig. 8

Analysis of oxidative stress in mice with hepatocellular carcinoma. Tumor growth of mice after hydrodynamic injection was analyzed by liver-body ratio (A) and histological hematoxylin–eosin staining at 3 days (B), 1 week (C) and 2 weeks (D) after injection of oncogenic plasmids. Measurement of total ROS levels using electrochemical microscopy (E), analysis of the expression of antioxidant defense enzymes (F) and proinflammatory cytokines (G) using RT-qPCR and serum ALT/AST levels (H). **p-value < 0.001