Fig. 7

Antitumor effects of free DOX, Lib-NS-DOX, and Apt-NS-DOX in xenograft tumor model. A Schematic diagram of the arrangement for the therapeutic experiments. After the treatment of free DOX, Lib-NS-DOX, and Apt-NS-DOX, the changes of B tumor volume and C body weight were measured (n = 5). Statistical analysis: **P < 0.01, ***P < 0.001. D The digital images of tumors dissected from the mice at the end of experiment (n = 5). E H&E and Ki67 IHC staining of tumor tissues in the free DOX, Lib-NS-DOX, and Apt-NS-DOX treated groups. F TUNEL staining of tumor tissues in the free DOX, Lib-NS-DOX, and Apt-NS-DOX treated groups. Green represented apoptotic cells and blue represented nuclei. Scale bars are 50 µm