Fig. 5

Therapeutic effect of PEM-ARM in vivo. A Sketch of the therapy regimen. B Survival curve of C57BL/6 mice exposed to pbANKA infection. C Weight change curves of C57BL/6 mice. D Flow cytometry detection of infection rate in mice (n = 5, ^* P < 0.05 and ^** P < 0.01). E Ring, F trophozoite, and G schizont stages of iRBCs changed in proportion. (n = 5, ^* P < 0.05 and ^** P < 0.01). H Reactive oxygen species and I mitochondria activity analysis of iRBCs treated with different drugs (n = 3, ^* P < 0.05 and ^** P < 0.01). J Mice lungs infected with pbANKA or treated with PBS, f-ARM, Lip-ARM, EM-ARM, or PEM-ARM, with mock-infected mice lungs as a control