Fig. 6

Characterizations of several measures of the safety of PEM-ARM. A Fluorescence images and B Median fluorescence intensity charts of MLE-12 cellular uptake after liposome treatment. Scale bar = 200 μm. Cell nuclei and the liposomes were labeled with HO (blue) and NR (red), respectively (n = 3, ^* P < 0.05 and ^** P < 0.01). C MTT assay after MLE-12 cells were incubated with various concentrations of liposomes (n = 6, ^* P < 0.05 and ^** P < 0.01). D H&E-stained slices of the liver, spleen, lung, kidney, brain, and heart. Scale bar = 200 μm, hemozoin (red arrow), glomerular capillary congestion sign (black frame)