Journal of Nanobiotechnology

Table 3 Evidence mapping of bone regeneration ability in included studies

From: Black phosphorous-based biomaterials for bone defect regeneration: a systematic review and meta-analysis

Outcome measure	BV/TV			BMD			Tb.N			Tb.Sp			Tb.Th
Measure time point Study	< 4 weeks	4–8 weeks*	≥ 8 weeks	< 4 weeks	4–8 weeks*	≥ 8 weeks	< 4 weeks	4–8 weeks*	≥ 8 weeks	< 4 weeks	4–8 weeks*	≥ 8 weeks	< 4 weeks	4–8 weeks*	≥ 8 weeks
Li et al. 2021 [35]		√	?					√	?					√	?
Xu et al. 2022 [36]		√	√		√	√
Miao et al. 2022 [37]		√√	√√		√√	√√
Li et al. 2022 [38]			√√			√√
Wang et al. 2018 [39]			√						√			√			√
Tong et al. 2019 [40]			√√
Hu et al. 2022 [41]		√√	√√					√√	√√		√√	√√		√√	√√
Qing et al. 2022 [42]		√√	√√								√	√
Wang et al. 2019a [43]			?			?
Wang et al. 2020 [44]		√	√		√	√
Wang et al. 2019b [45]		√√
Wu et al. 2021 [46]		√√	√√					√√	√√		√√	√√
Yang et al. 2018 [47]			√			√
Liu et al. 2022 [48]			√			√
Miao et al. 2019 [49]	√√	√√	√√	√√	√√	√√
Chen et al. 2020 [50]		√√	√√		√√	√√					√√	√√		√√	√√
Tan et al. 2022 [51]			?						?						?
Wang et al. 2021 [52]	√√	√√		-	√

*, include 4 weeks follow-up period; √√, p < 0.01 when compare with control group; √. p < 0.05 when compare with control group; -, p > 0.05 when compare with control group; ?, not clearly repot the difference when compare with control group; BV/TV, bone volume/tissue volume; BMD, bone mineral dense; Tb.N, trabecular number, Tb.Th, trabecular thickness; Tb.Sp, trabecular separation/spacing

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