Fig. 3
Multiple properties of Fe-PHCN@DOX nano-nuclear-reactors. A Temperature elevation curves of PBS and Fe-PHCN exposed to a 1064 nm NIR laser for 6 min. B Temperature elevation curves of Fe-PHCN with different concentrations under laser irradiation. Release curves of DOX from Fe-PHCN@DOX at different pH (C) and with or without NIR irradiation (D). E UV − vis spectra of MB aqueous solution from different groups. F UV − vis spectra of MB aqueous solution with Fe-PHCN and PHCN treatment. G UV − vis spectra of MB in Fe-PHCN solution treated with/without laser irradiation. H, I Intracellular ROS content was analyzed under DOX and DOX plus Catalase treatments using DCF as a ROS sensor. J GSH depletion under different concentrations of Fe-PHCN. (K) O2 generation of Fe-PHCN under with/without H2O2 treatment. The p values were analyzed using the Log-rank (Mantel-Cox) test. Data are presented as the mean ± standard error of the mean. *p < 0.05, **p < 0.01, ***p < 0.001