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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Extracellular matrix modulating enzyme functionalized biomimetic Au nanoplatform-mediated enhanced tumor penetration and synergistic antitumor therapy for pancreatic cancer

Fig. 2

PTT, PDT, and CT imaging effects, collagen degradation and NIR-triggered drug release of Col-M@AuNCs/Dox. a Infrared thermal images and (b) temperature curves under NIR irradiation. c Photothermal stability of Col-M@AuNCs/Dox after five cycles of irradiation and cooling. d ROS generation by Col-M@AuNCs/Dox upon NIR irradiation using DPBF as the probe. e CLSM observation of ROS detection in BxPC3 cells treated with AuNCs or Col-M@AuNCs/Dox with NIR irradiation (scale bar: 20 μm). f CT images and (g) quantitative CT values of AuNCs, M@AuNCs/Dox, Col-M@AuNCs/Dox and iohexol at varying Au or I concentrations of 0–5 mM. h CT linear fitting values of Col-M@AuNCs/Dox. i Fluorescein released by a FITC-containing collagen matrix treated with PBS, M@AuNCs/Dox, Col-M@AuNCs/Dox and collagenase. j M@AuNCs/Dox and Col-M@AuNCs/Dox diffusion into ECM-mimicking gels in capillary tubes (scale bar: 200 μm). k Dox release profiles from AuNCs/Dox, M@AuNCs/Dox and Col-M@AuNCs/Dox with and without NIR irradiation

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Journal of Nanobiotechnology

ISSN: 1477-3155

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