Fig. 9
From: Harnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolism
© 2022 Elsevier Ltd
A Illustration of the mechanism of MnFe2O4-DCA nanocomposites (SMDNs) in modulation of immunosuppressive TME. B TEM image and elemental mapping of the nanocomposites. C Cryogenic TEM images of mitochondrion localized in 4T1 cells treated with small SMDNs (~ 6 nm) or counterpart large MnFe2O4-DCA nanocomposites (LMDNs, ~ 10 nm). Arrows point to nanoparticles. D, E The expression of CD39 and CD73 on 4T1 cells. F–H The level of ATP, ADO and lactate in TME. I, J Tumor growth profile in bilateral tumor model. Reproduced with permission [132]. Copyright