Fig. 6

A Schedule of the establishment and treatment of OA mice. B The reconstructed micro-CT images revealed osteophyte formation to evaluate the therapeutic effect of MC NPs, MS NPs and MCS NPs on OA mice after treatment for four and eight weeks. C The relative articular space width of the medial compartments of mouse knee joints at four and eight weeks after surgery. n = 4. *p < 0.05. D Representative micro-CT reconstruction sagittal images of subchondral bone at weeks 4 and 8 after treatment. E Immunohistochemical staining of MMP13 in cartilage after treatment at weeks 4 and 8