Fig. 5

An efficient photothermal-augmented tumor therapeutic approach were developed, by regulating redox homeostasis concurrently with the activity of deubiquitinases, to convert the pro-survival unfolded protein response into the pro-apoptotic one. A Schematic illustration for the synthesis of tPF@PCM and the synergistic mechanism for cancer therapy. B T₂-weighted MR images of tumor-bearing mice at 0, 1, 3, 6, and 24 h post-injection. C Schematic of the treatment regimen for 786-O tumor-bearing mice. Figure adapted from Biao Cai et al. [113]