Phosphorothioated amino-AS1411 aptamer functionalized stealth nanoliposome accelerates bio-therapeutic threshold of apigenin in neoplastic rat liver: a mechanistic approach

Table 2 Results of biodistribution of experimental formulations

Organ/Tissues	Biodistribution of ^99mTc-labeled experimental nanoliposomes in HCC induced rat model
	^99mTc-NLCs		^99mTc-PEG-NLCs		^99mTc-Apt-NLCs
	4 h	8 h	4 h	8 h	4 h	8 h
Heart	0.587 ± 0.043	0.347 ± 0.065	0.489 ± 0.047	0.309 ± 0.028	0.199 ± 0.026	0.155 ± 0.007
Blood	2.538 ± 0.067	1.484 ± 0.091	5.8973 ± 0.53	2.369 ± 0.366	4.392 ± 0.201	2.523 ± 0.115
Liver	37.234 ± 0.33	18.899 ± 1.25	47.686 ± 1.92^#	33.078 ± 1.06	60.69 ± 1.63*	49.51 ± 0.478^
Lung	3.778 ± 0.209	2.554 ± 0.411	2.502 ± 0.295	2.678 ± 0.135	1.667 ± 0.349	2.319 ± 0.260
Spleen	0.627 ± 0.033	0.545 ± 0.036	0.833 ± 0.047	0.633 ± 0.106	0.724 ± 0.052	0.446 ± 0.042
Muscle	0.163 ± 0.013	0.142 ± 0.013	0.1893 ± 0.01	0.172 ± 0.022	0.118 ± 0.024	0.156 ± 0.011
Intestine	13.902 ± 0.29	8.988 ± 0.932	17.974 ± 0.61	14.27 ± 0.249	5.828 ± 0.074	3.651 ± 0.048
Stomach	0.487 ± 0.018	0.342 ± 0.028	0.653 ± 0.039	0.355 ± 0.012	0.387 ± 0.016	0.308 ± 0.032
Kidney	10.033 ± 0.71	4.461 ± 0.465	4.475 ± 0.276	3.254 ± 0.127	3.631 ± 0.406	2.591 ± 0.268
Urine	15.616 ± 0.14	14.706 ± 0.24	10.702 ± 0.82	9.755 ± 0.769	6.929 ± 0.851	5.654 ± 0.650

Data are expressed in % mean of injected dose (ID) per gram of organ/tissue ± SD (n = 3)
(#) Indicated significant (p < 0.05) amount of drug accumulation in liver in PEG-NLCs treated Gr over NLCs, while (*) indicated significant (p < 0.05) amount of drug accumulation in liver in Apt-PEG-NLCs treated Gr over PEG-NLCs Gr. at 4 h. (^) indicated significant (p < 0.05) amount of drug accumulation in liver in Apt-PEG-NLCs treated Gr over PEG-NLCs at 8 h

ISSN: 1477-3155