Fig. 4

In vitro efficacy. A Viabilities of PC9-GR4-AZD1 cells after treatment at different STAT3/EKEVs and free siSTAT3 concentrations. Two-way ANOVA. ****P < 0.0001. Error bars represent SEM (n = 3). B Schematic illustration of in vitro experimental procedures. C Cell scratch experiments (scale bar: 200 μm) and D corresponding quantification. One-way ANOVA. *P < 0.05. ns not significant. Error bars represent SEM (n = 3). E RT-PCR assays of STAT3 mRNA level in STAT3/EKEVs treated PC9-GR4-AZD1 cells