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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: Magnetofection of miR-21 promoted by electromagnetic field and iron oxide nanoparticles via the p38 MAPK pathway contributes to osteogenesis and angiogenesis for intervertebral fusion

Fig. 8

Electromagnetic field (EMF) enhanced transfection efficiency through the activation of p38 MAPK pathway. A, B Western blotting bands and corresponding protein expression levels of phosphorylated p38, p38, tau, and HAP27 (p-p38, p38, p-tau, p-HSP27, respectively). *p < 0.05, **p < 0.01, ***p < 0.001 compared to the control group. #p < 0.05, ##p < 0.01 compared to the EMF + PEI@IONPs + SB202190 group. C Fluorescence microscope images showing different transfection efficiencies under different treatments (control, EMF + PEI@IONPs, and EMF + PEI@IONPs + SB202190). D, E Immunofluorescence images of Runx2 (D) and CD31 (E) after various treatments (control, EMF + PEI@IONPs, and EMF + PEI@IONPs + SB202190). Runx2/CD31 was labelled with Cy3 (red), and nucleus were labelled with 4′,6-diamidino-2-phenylindole (DAPI, blue)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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