Fig. 2

Heatmaps of the Pearson correlation’s of CSF p-Tau181, CSF Aβ1-42, Qalb, Age, Sex and MMSE levels vs A neurology biomarkers and B inflammation biomarkers in CSF, plasma and pEVs samples of Aβ( +) and Aβ(-) EOMCI patients. Statistical analysis was performed with Fisher’s exact test. Baptista-Pike method was used to compute CI’s. Correlations of interest were set at Pearson r > 0.5 and r < − 0.5. p < 0.05 (*). pEVs neurology—CSF pTau181: p = 0.0007; CI (95%) = 0.000 to 0.3355/CSF neurology—CSF Aβ1− 42: p =  < 0.0001; CI (95%) = 5.090 to Infinity/CSF inflammation—CSF pTau181: p =  < 0.0001; CI (95%) = 0.06201 to 0.3390/CSF inflammation—Qalb: p = 0.0275; CI (95%) = 0.000 to 0.6870/CSF inflammation—Age: p =  < 0.0001; CI (95%) = 0.000 to 0.1544/Plasma inflammation—CSF pTau181: p = 0.0135; CI (95%) = 0.000 to 0.6799