Fig. 5

RNA-Seq analysis results of Nano-Se@S in zebrafish regeneration fin. A Heat maps of significantly upregulated and downregulated genes (fold change ≥ two and P < 0.05). B Gene Ontology (GO) enrichment analysis of the identified differentially expressed genes. The 30 most significantly enriched GO are shown. C Heat maps of significantly upregulated and downregulated genes related to FGF, Jak-STAT pathway, ROS metabolic process, and inflammatory response. D GSEA analysis of biomolecular synthesis. E GSEA analysis of reactive oxygen process. F GSEA analysis of immune system process